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Old 06-27-2008, 01:31 PM   #1
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Default Shar pei skin problems, atopica?

Has anyone got any experience of shar pei skin problems? well, f you've got a shar pei i'm guessing you have.

Basically he's on a hypo-allergenic diet, nothing else. Has a malaseb bath every other day, i've got fuciderm for the random sores and red blotches he gets and he's on 1 prednisolone 5mg a day, half morning, half night and STILL his legs, under body and feet are itchy. I reduced the steroids to the 5mg from 10mg a day. The itching is now minimal especially compared to what it used to be- he used to chew himself until he bled.

I don't know what else to do. He's had skin scrapings and no demotectic or sarcoptic mange.

Has anyone used Atopica? This has been suggested to me. Apparently most dogs can get severe sickness from the drug but what I have read suggests the side effects are not as bad as steroids.

Any advice would be much appreciated.

Alfie and Serens mum x

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Old 06-27-2008, 01:34 PM   #2
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I should add that the skin on the legs is still weak, brakes easily, is very dark in colour compared to skin he has which is normal and of course hair is missing from the legs and the under body.

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Old 06-27-2008, 01:51 PM   #3
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You might want to consider giving our dog a bath in Neem 40 shampoo - here's the link
http://www.neemgenie.co.uk/Merchant2...egory_Code=007
I'd use either Neem 40 skin treatment or Neem 40 medical. But in the meantime I've found some information on Atopic for you. Hope this helps.

Cyclosporine A (CsA) - Atopica® (Novartis) is a micro emulsion
formulation that improves absorption of the drug. The standard dosage
for atopic dermatitis is 5mg/kg per day. It is available in capsules of
10mg, 25mg, 50 mg and 100mg. Cyclosporine therapy may be more
practical in small dogs and cats due to expense. Atopica ® is most
consistently absorbed when given without food. However, giving with
food may decrease the likelihood of vomiting and other gastrointestinal
side effects. A recent study suggests that the administration of CsA
with food does not influence the clinical response or the frequency of
adverse events. CsA is metabolized by cytochrome P-450 enzymes.
Drugs that induce Cytochrome P-450 enzymes (phenobarbital and
rifampin) may decrease serum CsA levels. Likewise, drugs that inhibit
P-450 enzymes may increase CsA levels. Commonly used drugs that
inhibit P-450 enzyme systems include antifungals (ketoconazole,
itraconazole, fluconazole), furosemide, calcium channel blockers,
metaclopramide, methylprednisolone and doxycycline. Ketoconazole
specifically inhibits hepatic microsomal cytochrome P-450(CYP) 3A12
enzyme, the CYP that metabolizes cyclosporine and dexamethasone.
Consequently, ketoconazole may be given with cyclosporine to
decrease the amount of cyclosporine needed and decrease the cost of
therapy. This is especially important when considering cyclosporine
therapy in large dogs. Dosages of Atopica® of 2.5 -3 mg/kg per day
may be as effective as 5 mg/kg per day when given with generic
ketoconazole at 5 mg/kg per day. We recommend dosage of CsA
alone initially and establishing efficacy, before administration with
After control of pruritus is achieved, the clinician may be
able to reduce the daily dosage or switch to every second or third day
therapy.

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Old 06-27-2008, 02:08 PM   #4
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I have a shar pei mix, know several pure breeds, never seen one with those issues so sorry.. Can't the breeder help you??
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Old 06-27-2008, 02:12 PM   #5
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Thank you for your advice, the vets have said its something he will always have, we've just got to come up with a way of controlling it so he can live a comfortable life.

Thanks again.

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